RESUMO
Bile salts (BS) are bio-surfactants which constitute a vital component in the process of fat digestion. Despite the importance of the interfacial properties in their biological role, these have been scarcely studied in the literature. In this work, we present the adsorption-desorption profiles of two BS (NaTC and NaGDC) including dilatational rheology. Findings from this study reveal very different surface properties of NaTC and NaGDC which originate from different complexation properties relevant to the digestion process. Dynamic adsorption curves show higher adsorption rates for NaTC and suggest the existence of various conformational regimes in contrast to NaGDC which presents only one conformational regime. This is corroborated by analysis of the adsorption isotherms and more in detail by the rheological behaviour. Accordingly, the dilatational response at 1Hz displays two maxima of the dilatational modulus for NaTC as a function of bulk concentration, in contrast to NaGDC which displays only one maximum. The desorption profiles reveal that NaTC adopts an irreversibly adsorbed form at high surface coverage whereas NaGDC fully desorbs from the surface within the whole range of concentrations used. Analysis of the adsorption-desorption profiles provides new insight into the surface properties of BS, suggesting a surface complexation of NaTC. This knowledge can be useful since through interfacial engineering we might control the extent of lipolysis providing the basis for the rational design of food products with tailored digestibility.
Assuntos
Ar , Ácido Glicodesoxicólico/química , Ácido Taurocólico/química , Água/química , Adsorção , Módulo de Elasticidade , Reologia , Tensão Superficial , TemperaturaRESUMO
Health care workers (HCW) are included each year among risk groups for vaccination against influenza. However, vaccination coverage among this group in our country is very low, not exceeding 25%. Convinced that one of the best tools to increase this coverage among professionals in our country are the scientific evidence, 19 scientific societies and associations professionals bringing together health professionals more directly related to influenza as an health problem, and the General Nursing Council, met to discuss and develop this consensus document in order to inform HCW about the appropriateness of their vaccination against influenza and the benefits that flow from it for themselves, for their patients and for the rest of the population. This recommendation is based on 3 pillars: argument of necessity, ethics and exemplary.
Assuntos
Pessoal de Saúde , Influenza Humana/prevenção & controle , Vacinação/normas , Consenso , Guias como Assunto , Pessoal de Saúde/ética , Humanos , Vacinas contra Influenza , Espanha/epidemiologia , Vacinação/éticaRESUMO
No disponible
Assuntos
Humanos , Tuberculose Pulmonar/tratamento farmacológico , Antibacterianos/uso terapêutico , Resistência a Múltiplos MedicamentosAssuntos
Anticoagulantes/uso terapêutico , Heparina de Baixo Peso Molecular/uso terapêutico , Medicina Interna , Trombose Venosa/prevenção & controle , Uso de Medicamentos , Unidades Hospitalares/estatística & dados numéricos , Humanos , Pacientes Internados , Estudos Retrospectivos , Fatores de RiscoRESUMO
No disponible
